We study the role of long noncoding RNAs (lncRNA) in innate immunity and inflammation. We strive to integrate RNA biology and Immunology by asking fundamental questions relevant to gene regulation in innate immune cells. Our primary approach involves (1) Identification of context-specific lncRNAs in innate immune cells (e.g. macrophages and stromal cells) through RNA-sequencing, (2) Functional analysis in isolated cells using RNA perturbation strategies, and (3) Mechanistic studies by using RNA-centric tools. We pursue many questions relevant to gene regulation in innate immunity and inflammation, with lncRNAs and RNA-based regulatory mechanisms as our primary focus.

We aim to foster a  research environment of curiosity-driven science by a group of collaborative scientists.

Publications


HiChIRP reveals RNA-associated chromosome conformation


Maxwell R. Mumbach, Jeffrey M. Granja, Ryan A. Flynn, Caitlin M. Roake, Ansuman T. Satpathy, Adam J. Rubin, Yanyan Qi, Zhaozhao Jiang, Shadi Shams, Bryan H. Louie, Jimmy K. Guo, David G. Gennert, M. Ryan Corces, Paul A. Khavari, Maninjay K. Atianand, Steven E. Artandi, Katherine A. Fitzgerald, William J. Greenleaf, Howard Y. Chang

Nature Methods, vol. 16(6), 2019 Apr 31, pp. 489-492


Pyrin-only protein 2 limits inflammation but improves protection against bacteria


Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton

Nature Communications, vol. 8(1), 2017 Jun 31


Immunobiology of Long Noncoding RNAs


Maninjay K. Atianand, Daniel R. Caffrey, Katherine A. Fitzgerald

Annual Review of Immunology, vol. 35(1), 2017 Mar 25, pp. 177-198


A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation


Maninjay K. Atianand, Wenqian Hu, Ansuman T. Satpathy, Ying Shen, Emiliano P. Ricci, Juan R. Alvarez-Dominguez, Ankit Bhatta, Stefan A. Schattgen, Jason D. McGowan, Juliana Blin, Joerg E. Braun, Pallavi Gandhi, Melissa J. Moore, Howard Y. Chang, Harvey F. Lodish, Daniel R. Caffrey, Katherine A. Fitzgerald

Cell, vol. 165(7), 2016 Apr 31, pp. 1672-1685


IMMUNOLOGY. An RNA twist to T(H)17 cells.


Maninjay K. Atianand, Katherine A. Fitzgerald

Science, vol. 351(6277), 2016 Feb 3, pp. 1032-1032


View all

Contact


Maninjay Atianand

Principle Investigator


[email protected]


Immunology

University of Pittsburgh
200 Lothrop Street, Pittsburgh, PA 15261
Ph. 412-383-0472

Lab: BST W1000-15B, 16A-B
Office: BST W1046


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